TCM “Bigu” effect on serum vasoactive substances and possible primary prevention of cardiovascular diseases in sub-healthy Chinese women

Objective: To observe the intervention effect of TCM Bigu on serum vasoactive substances, as well as major physiological and biochemical indicators, and cardiovascular disease prevention in sub-healthy Chinese women who felt unwell but had no clear disease index. Methods: Eleven sub-healthy Chinese women aged 25-62 years, joined in and completed a 7-day TCM Bigu intervention. Changes in serum vasoactive substances (eNOS, NE, ET-I, ANG-II, INS), body composition, and major biochemical indicators as well as daily calorie intake at the beginning and end of the intervention were detected. Results: The serum eNOS in the 11 subjects significantly increased. The NE, ET-I, fasting INS, and HOMA-IR levels significantly decreased. The main indexes of body composition and biochemistry also changed significantly. Conclusion: Through this case study, we verified that Bigu can change the levels of serum vasoactive substances and major physiological/biochemical indicators, and decrease cardiovascular risk factors in sub-healthy women. Bigu is effective in preventing cardiovascular diseases in sub-healthy women. Keywords: Bigu, serum vasoactive substances, primary prevention, cardiovascular diseases